A novel dermal substitute using a resorbable bioactive scaffold to improve wound healing
Publication: Wound Repair and Regeneration
Start Page: A55
Chronic wounds such as diabetic foot ulcers cause much morbidity and burden on society. The major challenges in wound healing include reduced blood supply to the wound and disrupted epithelial closure, leading to increased infection risk, which impairs the healing even further. A variety of wound therapeutic options are currently available, nevertheless the neovascularization and reepithelialization are poorly addressed. Therefore the aim of this study was to examine the ability of a dermal substitute manufactured using a â€œbioresorbable aliphatic polyesterâ€ similar to types used in bioresorbable sutures but processed using a novel route, to promote vascularization and wound closure. The study was conducted using 10 diabetic and 11 non-diabetic Sprague-Dawley rats with bipedicle ischemic flap and six 6-mm punch wounds. Three of these wounds were randomly allocated square meshes of the scaffold (bioengineered dermal substitute). The wound areas were measured every second day and the animals were terminated at day 12 and 21 and the tissue was obtained for analysis of microscopic (histological tissue quality and vessel density), and mechanical properties (tensile strength). The scaffold improved the histological score of the diabetic ischemic wounds by improving the reepithelialization and granulation tissue quality. Moreover, the vessel density (CD31) was significantly higher (p = 0.0001) in ischemic wounds containing scaffold (6.1 Â± 8.9%) compared to ischemic wounds without scaffold (43.6 Â± 7.9%). However no effect on the wound healing rate or mechanical strength in the different wound groups was observed. In conclusion this scaffold supports the formation of vascular networks with cellular infiltrates, and reepithelialization on the surface of the scaffold, demonstrating its in vivo biocompatibility and bioactivity. With further modification and developments, this scaffold may offer an effective therapeutic option for wound healing.